블로그

./p>

20%) 10-year CVD risk based on FRS [21], and albuminuria measured as urine albumin to creatinine ratio (ACR) at 2-year post-baseline. Other secondary outcomes also at 2-year post-baseline included various thresholds of BP control, lifestyle measures (physical activity, body mass index (BMI), waist circumference, smoking status, intake of fruits and vegetables, dietary sodium intake (urinary sodium excretion)), clinical measures and outcomes (lipid levels, eGFR, dose of antihypertensive medications) [25], integrated 10-year CVD risk score (validated for a Chinese population) [26], fasting blood glucose (FBG), new-onset diabetes, and participant-reported health status. The latter was measured according to the mean score on the visual analogue scale (VAS) of the EQ-5D-5L (range, 0 to 100, with higher scores indicating better health) and mean score on the EQ-5D-5L utility index calculated using the Indonesian value set (range, −0.865 to 1, with higher scores indicating better health) [27]. In addition, the safety events included mortality, any serious adverse event (SAE), SAEs of special interest (cardiovascular death, hospitalization for CVDs due to coronary heart disease or acute coronary syndrome or elective revascularization or myocardial infarction, stroke, heart failure, peripheral vascular disease, and peripheral edema), adverse events (AEs), and hospitalizations potentially related to the intervention./p>

20%) 10-year CVD risk based on FRS was lower in the intervention arm with associated odds ratio (95% CI) 0.67 (0.47, 0.97) (p = 0.03) compared to usual care. Adjusted mean (95% CI) log albuminuria levels were lower by −0.22 (−0.41, −0.02) (log ACR) (p = 0.03) for intervention compared to usual care (Table 2). The number of antihypertensive medications used was higher by a mean (95% CI) of 0.18 (0.01, 0.36) (p = 0.04) per participant for intervention compared to usual care (Table 2) [25]. However, the mean DBP did not differ significantly between study arms (Table 2)./p> 0.20 for all) (Supporting information Table C)./p>34 mg/mmol, eGFR <60 ml/minute/1.73 m2, physician diagnosed heart disease, and self-reported stroke. gDiabetes is defined as physician diagnosed or FBS >7 mmol/L or glycated hemoglobin (HbA1c) >6.5%. hCKD is defined as eGFR <60 ml/minute/1.73 m2 or urine ACR ≥3 mg/mmol. ACR, albumin to creatinine ratio; BMI, body mass index; BP, blood pressure; CVD, cardiovascular disease; DBP, diastolic BP; eGFR, estimated glomerular filtration rate; FBS, fasting blood sugar; FRS, Framingham risk score; IPAQ, International Physical Activity Questionnaire; SBP, systolic BP./p>